The Systems Biology Laboratory investigates dynamic regulation and control mechanisms of cellular signal transduction networks by a combination of theoretical, experimental and computational methods. We seek to understand measured biological phenoma with the help of mathematical models, which ideally enable us to make valid predictions, thereby generating new biological insights.

The biological systems we investigate comprise

• Establishment and maintenance of DNA-damage induced cellular senescence in mammalian cells
• Response to hyper- and hypo- osmotic shock in yeast
• Response to arsenic stress in yeast

As theoretical method, we mainly employ ordinary differential equation systems, which we develop and analyse using a broad spectrum of analytical and computational tools.

In order to make valid and testable predictions, our gool is to parametrise our models using measured data. This is accomplished by global optimisation methods using high-end computation approaches.

 For further information on the group and their projects please visit www.sysbiolab.net.