Otto-von-Guericke-Universität Magdeburg

Institute of Experimental Internal Medicine


in press  2018 2017  2016  2015  2014  2013  2012  2011  2010   

in press

Gantenbein N, E Bernhart, I Anders, N Golob-Schwarzl, S Krassnig, C Wodlej, L Brcic, I Lindenmann, N Fink-Neuboeck, F Gollowitsch, E Stacher-Priehse, M Asslaber, M Gogg-Kamerer, J Rolff, J Hoffmann, A Silverstri, C Regenbrecht, C Reinhard, AM Pehserl, M Pichler, O Sokolova, M Naumann, V Mitterer, B Pertschy, H Bergler, H Popper, W Sattler, J Haybaeck. 2018. Influence of eukaryotic translation initiation factor 6 on non-small cell lung cancer development and progression. Eur J Cancer

Studencka-Turski M, G Maubach, MH Feige, M Naumann. 2018. Constitutive activation of nuclear factor kappa B-inducing kinase counteracts apoptosis in cells with rearranged mixed lineage leukemia gene. Leukemia


Publications 2018

Dubiel W, D Dubiel, DA Wolf, M Naumann. 2018. Cullin 3-based ubiquitin ligases as master regulators of mammalian cell differentiation. Trends Biochem Sci. 43:95-107. IF: 16,630

Feige M, O Sokolova, A Pickenhahn, G Maubach, M Naumann. 2018. HopQ impacts the integrin α5β1-independent NF-κB activation by Helicobacter pylori in CEACAM expressing cells. Int J Med Microbiol. 308:247-533. IF: 3,391

Feige MH, M Vieth, O Sokolova, C Täger, M Naumann. 2018. Helicobacter pylori induces direct activation of the lymphotoxin beta receptor and non-canonical nuclear factor-kappa B signaling. Biochim Biophys Acta. 1865:545-550. IF: 4,521

Fischer T, RC Braun-Dullaeus, M Naumann, J Kekow, PR Mertens, J Schreiber, A Canbay. 2018. Das internistische Jahr 2017 – Die wichtigsten Fortschritte und Entwicklungen. Ärzteblatt Sachsen-Anhalt. 29:17-20. IF: /

Lim M, G Maubach, M Naumann. 2018. NF‑kB‑regulated ubiquitin-editing enzyme A20 paves the way for infection persistency. Cell Cycle. 17:3-4. IF: 3,530

Mohr J, BP Dash, TM Schnoeder, D Wolleschak, C Herzog, NT Santamaria, S Weinert, S Godavarthy, C  Zanetti, M Naumann, B Hartleben, TB Huber, DS Krause, T Kähne, L Bullinger, FH Heidel. 2018. The cell fate determinant Scribble is required for maintenance of hematopoietic stem cell function. Leukemia. 32:1211-1221. IF: 11,702

Naghavi L, M Schwalbe, A Ghanem, M Naumann. 2018. Deubiquitinylase USP47 promotes RelA phosphorylation and survival in gastric cancer cells. Biomedicines. 6:E62. IF: /

Saik OV, PS Demenkov, TV Ivanisenko, EY Bragina, MB Freidin, IA Goncharova, VE Dosenko, OI Zolotareva, R Hofestaedt, IN Lavrik, EI Rogaev, VA Ivanisenko. 2018. Novel candidate genes important for asthma and hypertension comorbidity revealed from associative gene networks. BMC Med Genomics.11:15. IF: 2,848

Senichkin VV, GS Kopeina, EA Prokhorova, AV Zamaraev, IN Lavrik, B Zhivotosky. 2018. Modulation of Mcl-1 transcription by serum deprivation sensitizes cancer cells to cisplatin. Biochim Biophys Acta. 1862:557-566. IF: 4,702

Sokolova O, T Kähne, K Bryan, M Naumann. 2018. Interactome analysis of transforming growth factor-β-activated kinase 1 in Helicobacter pylori-infected cells revealed novel regulators tripartite motif 28 and CDC37. Oncotarget. 9:14366-14381. IF: 5,168


Publications 2017

Backert S, R Haas, M Gerhard, M Naumann. 2017. The Helicobacter pylori type IV secretion system encoded by the cag pathogenicity island: architecture, function and signaling. Curr Topics Microbiol Immunol. 413:187-220. IF: 3,719

Bettermann K. 2017. NF-κB and its implication in liver health and cancer development. Mech Mol Carcino. 1:87-114. IF: /

Boege Y, M Malehmir, ME Healy, K Bettermann, A Lorentzen, M Vucur, AK Ahuja, F Böhm, J Mertens, Y Shimizu, L Frick, C Remouchamps, K Mutreja, T Kähne, D Sundaravinayagam, M Wolf, H Rehrauer, C Koppe, T Speicher, S Padrissa-Altés, R Maire, JM Schattenberg, J Jeong, L Liu, S Zwirner, R Boger, N Hüser, RJ Davis, B Müllhaupt, H Moch, H Schulze-Bergkamen, PA Clavien, S Werner, L Borsig, SA Luther, P Jost, R Weinlich, K Unger, A Behrens, L Hillert, C Dillon,, M Di Virgilio, D Wallach, E Dejardin, L Zender, M Naumann, H Walczak, DR Green, M Lopes, I Lavrik, T Luedde, M Heikenwalder, A Weber. 2017. A dual role of caspase 8 in triggering and sensing proliferation-associated DNA damage, a key determinant of liver cancer development. Cancer Cell. 32:342-359e10. IF: 27,407

Caviedes A, M Varas-Godoy, CA Lafourcade, S Sandoval, JB Bravo-Alegria, T Kaehne, AG Massmann, JP Figueroa, FJ Nualart, U Wyneken. 2017. Endothelial nitric oxide synthase is present in dendritic spines of neurons in primary cultures. Front Cell Neurosci. 11:180. IF: 4,555

Dubiel D, W Bintig, T Kähne, W Dubiel, M Naumann. 2017. Cul3 neddylation is crucial for gradual lipid droplet formation during adipogenesis. Biochim Biophys Acta. 1864:1405-1412. IF: 4,521

Fernández-Orth J, P Ehling, T Ruck, S Pankratz, MS Hofmann, P Landgraf, DC Dieterich, KH Smalla, T Kähne, G Seebohm, T Budde, H Wiendl, S Bittner, SG Meuth. 2017. 14-3-3 proteins regulate K2P 5.1 surface expression on T lymphocytes. Traffic. 18:29-43. IF: 4,133

Figueiredo AS. 2017. Data sharing: Convert challenges into opportunities. Front Public Health. 5:327. IF: /

Figueiredo AS, T Kouril, D Esser, P Haferkamp, P Wieloch, D Schomburg, P Ruoff, B Siebers, J Schaber. 2017. Systems biology of the modified branched Entner-Doudoroff pathway in Sulfolobus solfataricus. PLoS One. 12:e180331. IF: 2,806

Haurat MF, AS Figueiredo, L Hoffmann, L Li, K Herr, A Wilson, M Beeby, J Schaber, SV Albers. 2017. ArnS, a kinase involved in starvation-induced archaellum expression. Mol Microbiol. 103:181-194. IF: 3,898

Korthals M, K Langnaese, KH Smalla, T Kähne, R Herrera-Molina, J Handschuh, AC Lehmann, D Mamula, M Naumann, C Seidenbecher, W Zuschratter, K Tedford, ED Gundelfinger, D Montag, KD Fischer, U Thomas. 2017. A complex of neuroplastin and plasma membrane Ca2+ ATPase controls T cell activation. Sci Rep. 7:8358. IF: 4,259

Lim M, G Maubach, O Sokolova, MH Feige, R Diezko, J Buchbinder, S Backert, D Schlüter, IN Lavrik, M Naumann. 2017. Pathogen-induced ubiquitin-editing enzyme A20 bifunctionally shuts off NF-kB and caspase 8-dependent apoptotic cell death. Cell Death Differ. 24:1621-1631. IF: 8,339

Maubach G, M Naumann. 2017. NEMO links NF‑kB to human diseases. Trends Mol Med. 23:1138-1155. IF: 10.732

Mertens PR, RC Braun-Dullaeus, J Schreiber, A Canbay, M Naumann, T Fischer, J Kekow. 2017. Das internistische Jahr 2016 – Die wichtigsten Fortschritte und Entwicklungen. Ärzteblatt Sachsen-Anhalt. 28:19-22. IF: /

Naumann M, O Sokolova, N Tegtmeyer, S Backert. 2017. Helicobacter pylori: a paradigm pathogen for subverting host cell signal transmission. Trends Microbiol. 25:316-328. IF: 11,020

Petrovskaya CV, ED Petrovskiy, IN Lavrik, VA Ivanisenko. 2017. A study of structural properties of gene network graphs for mathematical modeling of integrated mosaic gene networks. J Bioinform Comput Biol. 15:16550-16545. IF: 0,800

Pietkiewicz S, C Wolfe, JH Buchbinder, IN Lavrik. 2017. Measuring procaspase-8 and -10 processing upon apoptosis induction. Bio Protoc. 7:e2081. IF: /

Ranjan S, A Goihl, S Kohli, I Gadi, M Pierau, K Shahzad, D Gupta, F Bock, H Wang, H Shaikh, T Kähne, D Reinhold, U Bank, A Zenclussen, J Niemz, T Schnöder, M Brunner-Weinzierl, T Fischer, T Kalinski, B Schraven, T Luft, J Huehn, M Naumann, F Heidel, B Isermann. 2017. Activated protein C protects from GvHD via PAR2/PAR3 signalling in regulatory T-cells. Nat Commun. 8:311. IF: 12,124

Saik OV, NA Konovalova, PS Demenkov, NV Ivanisenko, T V Ivanisenko, DE Ivanoshchuk, O S Konovalova, OA Podkolodnaya, IN Lavrik, NA Kolchanov, VA Ivanisenko. 2017. Molecular mechanisms of the interaction between the processes of the cell response to mechanical stress and neuronal apoptosis in primary open-angle glaucoma. Russ J Genet. 7:558-564. IF: /

Schmid U, W Stenzel, J Koschel, M Raptaki, X Wang, M Naumann, K Matuschewski, D Schlüter, G Nishanth. 2017. The deubiquitinating enzyme cylindromatosis dampens CD8+ T cell responses and is a critical factor for experimental cerebral malaria and blood-brain barrier damage. Front Immunol. 8. IF: 6,429

Sokolova O, M Naumann. 2017. NF-κB signaling in gastric cancer. Toxins. 9:119. IF: 3,030

Studencka M, J Schaber. 2017. Senoptosis: non-lethal DNA cleavage as a route to deep senescence. Oncotarget. 8:30656-30671. IF: 5,168                       

Tegtmeyer N, S Wessler, V Necchi, M Rohde, A Harrer, TT Rau, CI Asche, M Boehm, H Loessner, C Figueiredo, M Naumann, R Palmisano, E Solcia, V Ricci, S Backert. 2017. Helicobacter pylori employs a unique basolateral type IV secretion mechanism for CagA delivery. Cell Host Microbe. 22:552-560. IF: 14,946

Yazdi S, M Naumann, M Stein. 2017. Double phosphorylation-induced structural changes in the signal-receiving domain of IκBα in complex with NF-κB. Proteins. 85:17-29. IF: 2,289

Zamaraev AV, GS Kopeina, EA Prokhorova, B Zhivotovsky, IN Lavrik. 2017. Post-translational modification of caspases: the other side of apoptosis regulation. Trends Cell Biol. 75:322-339. IF: 15,333

Zimmermann S, L Pfannkuch, MA Al-Zeer, S Bartfeld, M Koch, J Liu, C Rechner, M Soerensen, O Sokolova, A Zamyatina, P Kosma, AP Mäurer, F Glowinski, KP Pleissner, M Schmid1, V Brinkmann, M Naumann, M Rother, N Machuy, TF Meyer. 2017. ALPK1 and TIFA dependent innate immune response triggered by the Helicobacter pylori type IV secretion system. Cell Rep. 20:2384-2395. IF: 8,282


Publications 2016

Aksenova VI, GS Kopeina, Av Zamaraev, BD Zhivotovskiy, IN Lavrik. 2016. Mechanism of caspase-2 activation upon DNA damage. Dokl Biochem Biophys. 467.132-135. IF: 0,394

Backert S, M Neddermann, G Maubach, M Naumann. 2016. Pathogenesis of Helicobacter pylori infection. Helicobacter. 21 Suppl 1:19-25. IF: 3,920

Börsch A, J Schaber. 2016. How time delay and network design shape response patterns in biochemical negative feedback systems. BMC Syst Biol.10:82. IF: 2,213

Braun-Dullaeus RC, PR Mertens, J Schreiber, P Malfertheiner, M Naumann, T Fischer, J Kekow. 2016. Das internistische Jahr 2015 – die wichtigsten Fortschritte und Entwicklungen. Ärzteblatt Sachsen-Anhalt. 27:19-22. IF: /

Figueiredo AS, A Schumacher. 2016. The T helper type 17/regulatory T cell paradigm in pregnancy. Immunology. 148:13-21. IF: 4,078

Gummlich L, T Kähne, M Naumann, E Kilic, K Jung, W Dubiel. 2016. New insights into the mechanism of COP9 signalosome Cullin-RING Ubiquitin-Ligase pathway deregulation in urological cancers. Int Rev Cell Mol Biol. 323:181-229. IF: 3,752

Ivanisenko NV, L Hillert, VA Ivanisenko, IN Lavrik. 2016. Design and experimental validation of small-molecule inhibitors of the FADD protein. RUSS J GENET+.6:778-784. IF: 0,448

Ivanisenko NV, IN Lavrik, VA Ivanisenko. 2016. Computer simulation of the spatial structures of MUC1 peptides capable of inhibiting apoptosis. RUSS J GENET+.6:771-777. IF: 0,448

Just S, G Nishanth, J Buchbinder, X Wang, M Naumann, I Lavrik, D Schlüter. 2016. A20 curtails primary but augments secondary CD8+ T cell responses in intracellular bacterial infection. Sci Rep. 6:39796. IF: 5,228

Kähne T, S Richter, A Kolodziej, KH Smalla, R Pielot, A Engler, FW Ohl, DC Dieterich, C Seidenbecher, W Tischmeyer, M Naumann, ED Gundelfinger. 2016. Proteome rearrangements after auditory learning: high-resolution profiling of synapse-enriched protein fractions from mouse brain. J Neurochem. 138:124-138. IF: 3,842

Kasiri MM, L Beer, L Nemec, F Gruber, S Pietkiewicz, T Haider, EM Simader, D Traxler, T Schweiger, S Janik, S Taghavi, C Gabriel, M Mildner, HJ Ankersmit. 2016. Dying blood mononuclear cell secretome exerts antimicrobial activity. Eur J Clin Invest. 46:853-863. IF:2,687

Kleber J, YC Chen, B Michels, T Saumweber, M Schleyer, T Kähne, E Buchner, B Gerber. 2016. Synapsin is required to "boost" memory strength for highly salient events. Learn Mem. 23:9-20. IF: 2,906

Kollarovic G, M Studencka, L Ivanova, C Lauenstein, K Heinze, A Lapytsko, SR Talemi, AS Figueiredo, J Schaber. 2016. To senesce or not to senesce: how primary human fibroblasts decide their cell fate after DNA damage. Aging. 8:158-177. IF: 3,979

Kolodziej A, KH Smalla, S Richter, A Engler, R Pielot, D Dieterich, W Tischmeyer, M Naumann, T Kähne. 2016. High resolution quantitative synaptic proteome profiling of mouse brain regions after auditory discrimination learning. J Vis Exp. 118:e54992. IF: 1,113

Kopeina GS, AV Zamaraev, BD Zhivotovsky, IN Lavrik. 2016. Identification of new complex for caspase-2 activation after DNA damage. Russ J Bioorganic Chem. 42:74-82. IF: 0,660

Lange M, J Schaber, A Marx, G Jäckel, FW Badeck, R Seppelt, D Doktor. 2016. Simulation of forest tree species` bud burst dates for different climate scenarios: chilling requirements and photo-period may limit bud burst advancement. Int J Biometeorol. 60:1711-1726. IF: 2,309

Lapytsko A, J Schaber. 2016. The role of time delay in adaptive cellular negative feedback systems. J Theor Biol. 398:64-73 IF: 2,049

Lavrik IN, MG Samsonaova. 2016. The systems biology of signaling pathways. Biophysics. 61:78-84. IF: /

Möhle L, N Israel, K Paarmann, M Krohn, S Pietkiewicz, A Müller, IN Lavrik, JS Buguliskis, BH Schott, D Schlüter, ED Gundelfinger, D Montag, U Seifert, J Pahnke, IR Dunay. 2016. Chronic Toxoplasma gondii infection enhances β-amyloid phagocytosis and clearance by recruited monocytes. Acta Neuropathol Commun. 4:25. IF: /

Oh IS, K Textoris-Taube, PS Sung, W Kang, X Gorny, T Kähne, SH Hong, YJ Choi, C Cammann, M Naumann, JH Kim, SH Park, OJ Yoo, PM Kloetzel, U Seifert, EC Shin. 2016. Immunoproteasome induction is suppressed in hepatitis C virus-infected cells in a protein kinase R-dependent manner. Exp Mol Med. 48:e270. IF: 5,164

Popik OV, TV Ivanisenko, OV Saik, ED Petrovskiy, IN Lavrik, VA Ivanisenko. 2016. NACE: A web-based tool for prediction of intercompartmental efficiency of human molecular genetic networks. Virus Res. 218:79-85. IF: 2,526

Popik OV, ED Petrovskiy, EL Mishchenko, IN Lavrik, VA Ivanisenko. 2016. Mosaic gene network modelling identified new regulatory mechanisms in HCV infection. Virus Res. 218:71-78. IF: 2,526

Schleich K, JH Buchbinder, S Pietkiewicz, T Kähne, U Warnken, S Öztürk, M Schnölzer, M Naumann, PH Krammer, IN Lavrik. 2016. Molecular architecture of the DED chains at the DISC: Regulation of procaspase-8 activation by short DED proteins c-FLIP and procaspase-8 prodomain. Cell Death Differ. 23:681-694. IF: 8,218

Schweitzer K, A Pralow, M Naumann. 2016. P97/VCP promotes cullin-RING-ubiquitin-ligase/proteasome-dependent degradation of IκBa and the preceding liberation of RelA from ubiquitinated IκBa. J Cell Mol Med. 20:58-70. IF: 4,938

Senichkin VV, GS Kopeina, AV Zamaraev, IN Lavrik, BD Zhivotovsky. 2016. Nutrient restriction in combinatory therapy of tumors. Mol Biol (Mosk).50:362-378. IF: 0,612

Talemi SR, CF Tiger, M Andersson, R Babazadeh, N Welkenhuysen, E Klipp, S Hohmann, J Schaber. 2016. Systems level analysis oft he yeast osmo-stat. Sci Rep. 6:30950. IF: 5,228

Wex K, U Schmid, S Just, X Wang, R Wurm, M Naumann, D Schlüter, G Nishanth. 2016. Receptor-interacting protein kinase-2 inhibition by CYLD impairs antibacterial immune responses in macrophages. Front Immunol. 6:00650. IF: 5,695

Zimmer C, K Schleich, I Lavrik. 2016. Parameter identification using stochastic simulations reveals a robustness in CD95 apoptotic response. Mol Biosyst. 12:1486-1495 IF: 2,829


Publications 2015

Boehme JD, S Pietkiewicz, I Lavrik, A Jeron, D Bruder. 2015. Morphological and functional alterations of alveolar macrophages in a murine model of chronic inflammatory lung disease. Lung. 193:947-953. IF: 2,271

Dorosz S, A Ginolhac, T Kähne, M Naumann, T Sauter, A Salsmann, JL Bueb. 2015. Role of calprotectin as a modulator of the IL-27-mediated pro-inflammatory effect on endothelial cells. Mediators Inflamm. 2015: ID 737310, 16 pages. IF: 3,236

Dubiel D, J Ordemann, J Pratschke, W Dubiel, M Naumann. 2015. CAND1 exchange factor promotes Keap1 integration into cullin 3-RING ubiquitin ligase during adipogenesis. Int J Biochem Cell Biol. 66:95-100. IF: 4,046

Dubiel D, B Rockel, M Naumann, W Dubiel. 2015. Diversity of COP9 signalosome structures and functional consequences. FEBS Lett. 589:2507-2513. IF: 3,169

Lapytsko A, G Kollarovic, L Ivanova, M Studencka, J Schaber. 2015. FoCo: a simple and robust quantification algorithm of nuclear foci. BMC Bioinformatics. 16:392 IF: 2,576

Medunjanin S, JM Daniel, S Weinert, J Dutzmann, F Burgbacher, S Brecht, D Bruemmer, T Kähne, M Naumann, DG Sedding, W Zuschratter, RC Braun-Dullaeus. 2015. DNA-dependent protein kinase (DNA-PK) permits vascular smooth muscle cell proliferation through phosphorylation of the orphan nuclear receptor NOR1. Cardiovasc Res. 106:488-497. IF: 5,940

Mkrtchyan G, V Aleshin, Y Parkhomenko, T Kähne, ML di Salvo, A Parroni, R Contestabile, A Vovk, L Bettendorff, V Bunik. 2015. Molecular mechanisms of the non-coenzyme action of thiamin in brain: biochemical, structural and pathway analysis. Sci Rep. 5:12583. IF: 5,578

Niewalda T, B Michels, R Jungnickel, S Diegelmann, J Kleber, T Kähne, B Gerber. 2015. Synapsin determines memory strength after punishment- and relief-learning. J Neurosci. 35:7487-7502. IF: 6,344

Petrovskiy ED, OV Saik, ES Tiys, IN Lavrik, NA Kolchanov, VA Ivanisenko. 2015. Prediction of tissue-specific effects of gene knockout on apoptosis in different anatomical structures of human brain. BMC Genomics. 16 Suppl 13:S3 IF: 3,986

Pietkiewicz S, R Eils, PH Krammer, N Giese, IN Lavrik. 2015. Combinatorial treatment of CD95L and gemcitabine in pancreatic Cancer cells induces apoptotic and RIP1-mediated necroptotic cell death network. Exp Cell Res. 339:1-9. IF: 3,246

Pietkiewicz S, JH Schmidt JH, IN Lavrik. 2015. Quantification of apoptosis and necroptosis at the single cell level by a combination of Imaging Flow Cytometry with classical Annexin V/propidium iodide staining. J Immunol Methods. 423:99-103. IF: 1,820

Prokhorova EA, AV Zamaraev, GS Kopeina, B Zhivotovsky, IN Lavrik. 2015. Role of the nucleus in apoptosis: signaling and execution. Cell Mol Life Sci. 72:4593-4612. IF: 5,808

Rastgou Talemi S, G Kollarovic, A Lapytsko, J Schaber. 2015. Development of a robust DNA damage model including persistent telomere-associated damage with application to secondary cancer risk assessment. Sci Rep. 5:13540. IF: 5,578

Reichenbach N, U Herrmann, T Kähne, H Schicknick, R Pielot, M Naumann, DC Dieterich, ED Gundelfinger, KH Smalla, W Tischmeyer. 2015. Differential effects of dopamine signalling on long-term memory formation and consolidation in rodent brain. Proteome Sci. 13:13. IF: 1,725

Schmidt JH, S Pietkiewicz, M Naumann, IN Lavrik. 2015. Quantification of CD95-induced apoptosis and NF-κB activation at the single cell level. J Immunol Methods. 423:12-17. IF: 1,820

Schweitzer K, M Naumann. 2015. CSN-associated USP48 confers stability to nuclear NF-kappaB/RelA by trimming K48-linked Ub-chains. Biochim Biophys Acta. 1853:453-469. IF: 5,019

Wurm R, S Just, X Wang, K Wex, U Schmid, N Blanchard, A Waisman, HJ Schild, M Naumann, D Schlüter, G Nishanth. 2015. Protective dendritic cell responses against listeriosis induced by the short form of the deubiquitinating enzyme CYLD are inhibited by full-length CYLD. Eur J Immunol. 45:1366-1376. IF: 4,034

Xuan NT, X Wang, G Nishanth, A Waisman, K Borucki, B Isermann, M Naumann, M Deckert, D Schlüter. 2015. A20 expression in dendritic cells protects against LPS-induced mortality. Eur J Immunol. 45:818-828. IF: 4,034

Yazdi S, S Durdagi, M Naumann, M Stein. 2015. Structural modeling of the N-terminal signal–receiving domain of IκBα. Front Mol Biosci. 2:32 IF: -,-

Zamaraev AV, GS Kopeina, B Zhivotovsky, IN Lavrik. 2015. Cell death controlling complexes and their potential therapeutic role. Cell Mol Life Sci. 72:505-517. IF: 5,808


Publications 2014

Bettermann K, T Hohensee, J Haybaeck. 2014. Steatosis and steatohepatitis: complex disorders. Int J Mol Sci. 15:9924-9944 IF: 2,339

Dieterle AM, P Böhler, H Keppeler, S Alers, N Berleth, S Drießen, N Hieke, S Pietkiewicz, AS Löffler, C Peter, A Gray, NR Leslie, H Shinohara, T Kurosaki, M Engelke, J Wienands, M Bonin, S Wesselborg, B Stork. 2014. PDK1 controls upstream PI3K expression and PIP3 generation. Oncogene. 5:33:3043-3053. IF: 8,559

Flassig R, G Maubach, C Täger, K Sundmacher, M Naumann. 2014. Experimental design, validation and computational modeling uncover DNA damage sensing by DNA-PK and ATM. Mol. Biosyst. 10:1978-1986. IF: 3,183

Lavrik IN. 2014. Systems biology of death receptor networks: live and let die. Cell Death Dis. 5:e1259. IF: 5,177

Lavrik IN, B Zhivotovsky. 2014. Systems biology: a way to make complex problems more understandable. Cell Death Dis. 5:e1259. 5,177

Popik OV, OV Saik, ED Petrovskiy, B Sommer, R Hofestädt, IN Lavrik, VA Ivanisenko. 2014. Analysis of signaling networks distributed over intracellular compartments based on protein-protein interactions. BMC Genomics. 15 Suppl 12:S7. IF: 4,041

Rastgou Talemi S, T Jacobson, V Garla, C Navarrete, A Wagner, MJ Tamás, J Schaber. 2014. Mathematical modeling of arsenic transport, distribution and detoxification processes in yeast. Mol Microbiol. 92:1343-1356. IF: 5,026

Schaber J, A Lapytsko, D Flockerzi. 2014. Nested autoinhibitory feedbacks alter the resistance of homeostatic adaptive biochemical networks. J R Soc Interface. 11:20130971. IF: 3,856

Sokolova O, G Maubach, M Naumann. 2014. MEKK3 and TAK1 synergize to activate IKK complex in Helicobacter pylori infection. Biochim Biophys Acta. 1843:715-724. IF: 5,297

Sokolova O, M Vieth, Gnad T, Bozko PM, Naumann M. 2014. Helicobacter pylori promotes eukaryotic protein translation by activating phosphatidylinositol 3 kinase/mTOR. Int J Biochem Cell Biol. 55C:157-163. IF: 4,240


Publications 2013

Dierenbach J, FW Badeck, J Schaber. 2013. The plant phenological online database (PPODB): an online database for long-term phenological data. Int J Biometeorol. 57:805-812. IF: 2,590

Diesing AK, C Nossol, H Faber-Zuschratter, W Zuschratter, L Renner, O Sokolova, M Naumann, HJ Rothkötter. 2013. Rapid interaction of Helicobacter pylori with microvilli of the polar human gastric epithelial cell line NCI-N87. Anat Rec. 296:1800-1805. IF: 1,343

Dubiel D, ME Gierisch, X Huang, W Dubiel, M Naumann. 2013. CAND1-dependent control of cullin 1-RING Ub ligases is essential for adipogenesis. Biochim Biophys Acta. 1833:1078-1084. IF: 4,808

Fricker N, IN Lavrik. 2013. Modeling Single Cells in Systems Biology. In: ‚Systems Biology of apoptosis’. Publ. Springer. p.145-162. IF: -,-

Kanakis D, U Lendeckel, P Theodosiou, H Dobrowolny, C Mawrin, G Keilhoff, A Bukowska, K Dietzmann, B Bogerts, HG Bernstein. 2013. ADAM 12: A putative marker of oligodendrogliomas? Dis Markers. 34:81-91. IF: 2,140

Karpova A, M Mikhaylova, S Bera, J Bär, PP Reddy, T Behnisch, V Rankovic, C Spilker, P Bethge, J  Sahin, R Kaushik, W Zuschratter, T Kähne, M Naumann, ED Gundelfinger, MR Kreutz. 2013. Encoding and transducing the synaptic or extrasynaptic origin of NMDA receptor signals to the nucleus. Cell. 152:1119-1133. IF: 31,957

Lavrik IN. 2013. book 'Systems biology of apoptosis'. Publ. Springer. 

Lee JH, L Yi, J Li, K Schweitzer, M Borgmann, M Naumann, H Wu. 2013. Crystal structure and versatile functional roles of the COP9-signalosome subunit 1. Proc Natl Acad Sci USA. 110:11845-11850. IF: 9,737

Maubach G, O Sokolova, M Wolfien, HJ Rothkötter, M Naumann. 2013. Ca2+/calmodulin-dependent kinase II contributes to inhibitor of nuclear factor-kappa B kinase complex activation in Helicobacter pylori infection. Int J Cancer. 133:1507-1512. IF: 6,198

Nishanth G, M Deckert, K Wex, R Massoumi, K Schweitzer, M Naumann, D Schlüter. 2013. CYLD enhances severe listeriosis by impairing IL-6/STAT3-dependent fibrin production. PLoS Pathog. 9:e1003455. IF: 8,136

Öztürk S, K Schleich, IN Lavrik. 2013. CASP8 (Caspase 8, Apoptosis-Related Cysteine Peptidase). Atlas Genet Cytogenet Oncol Haematol. 

Ortloff AR, K Vio, M Guerra, K Jaramillo, T Kaehne, H Jones, JP McAllister II, E Rodriguez. 2013. Role of the subcommissural organ in the pathogenesis of congenital hydrocephalus in the HTx rat. Cell Tissue Res. 352:707-725. IF: 3,677

Petelenz-Kurdziel E, C Kuehn, B Nordlander, D Klein, KK Hong, T Jacobson, P Dahl, J Schaber, J Nielsen, S Hohmann, E Klipp. 2013. Quantitative analysis of glycerol accumulation, glycolysis and growth under hyper osmotic stress. PLoS Comput Biol. 9:e1003084. IF:4,867

Pietkiewicz S, D Sohn, RP Piekorz, S Grether-Beck, W Budach, K Sabapathy, RU Jänicke. 2013. Oppositional regulation of Noxa by JNK1 and JNK2 during apoptosis induced by proteasomal inhibitors. PLoS One. 8:e61438. IF: 3,730

Rickert D, N Fricker, IN Lavrik, FJ Theis. 2013. Systematic Complexity Reduction of Signaling Models and Application to a CD95 Signaling Model for Apoptosis. In: ‚Systems Biology of apoptosis’. Publ. Springer. p 57-84. IF: -,-

Schleich K, PH Krammer, IN Lavrik. 2013. The chains of death: A new view on caspase-8 activation at the DISC. Cell Cycle. 12:193-194. IF: 5,243

Schleich K, IN Lavrik. 2013. Mathematical modeling of apoptosis. Cell Commun Signaling. 11:44. IF: 5,039

Schleich K, IN Lavrik. 2013. Systems Biology of Death Receptor-Induced Apoptosis. In: ‚Systems Biology of apoptosis’. Publ. Springer. p.33-57. IF: -,-

Sokolova O, M Borgmann, C Rieke, K Schweitzer, HJ Rothkötter, M Naumann. 2013. Helicobacter pylori induces type 4 secretion system-dependent, but CagA-independent activation of IκBs and NF-κB/RelA at early time points. Int J Med Microbiol. 303:548-552. IF: 4,537

Sokolova O, M Vieth, M Naumann. 2013. Protein kinase C isozymes regulate matrix metalloproteinase-1 expression and cell invasion in Helicobacter pylori infection. Gut. 62:358-367. IF: 10,732

Walluscheck D, A Poehlmann, R Hartig, U Lendeckel, P Schönfeld, A Hotz-Wagenblatt, K Reissig, K Bajbouj, A Roessner, R Schneider-Stock. 2013. ATF2 knockdown reinforces oxidative stress-induced apoptosis in TE7 cancer cells. J Cell Mol Med. 17:976-988. IF: 4,753

Wang X, M Deckert, NT Xuan, G Nishanth, S Just, A Waisman, M Naumann, D Schlüter. 2013. Astrocytic A20 ameliorates experimental autoimmune encephalomyelitis by inhibiting NF-κB- and STAT1-dependent chemokine production in astrocytes. Acta Neuropathol. 126:711-724. IF: 9,734

Warnken U, K Schleich, M Schnölzer, IN Lavrik. 2013. Quantification of High-Molecular Weight Protein Platforms by AQUA Mass Spectrometry as Exemplified for the CD95 Death-Inducing Signaling Complex (DISC). Cells. 2: 476-495. IF: -,-


Publications 2012

Bien J, O Sokolova, P Bozko. 2012. Role of uropathogenic Escherichia coli virulence factors in development of urinary tract infection and kidney damage. Int J Nephrol 2012. 1-15. IF: -,-

Buss H, K Handschick, N Jurrmann, P Pekkonen, K Beuerlein, H Müller, R Wait, J Saklatvala, PM Ojala, ML Schmitz, M Naumann, M Kracht. 2012. Cyclin-dependent kinase 6 phosphorylates NF-κB p65 at serine 536 and contributes to the regulation of inflammatory gene expression. PLoS One. 7:e51847. IF: 4,092

Goihl A, AM Rolle, T Kähne, A Reinhold, S Wrenger, D Reinhold. 2012. Methodologic issues in the measurement of interleukin-16 in clinical blood samples using immunoassays. Cytokine 58:1-5. IF: 3,019

Kähne T, A Kolodziej, KH Smalla, E Eisenschmidt, UU Haus, R Weismantel, S Kropf, W Wetzel, F-W Ohl, W Tischmeyer, M Naumann, ED Gundelfinger. 2012. Synaptic proteome changes in mouse brain regions upon auditory discrimination learning. Proteomics. 12:2433-2444. IF: 4,505

Lavrik IN, PH Krammer. 2012. Regulation of CD95/Fas signaling at the DISC. Cell Death Differ. 1:36-41. IF: 8,371

Oztürk S, K Schleich, IN Lavrik. 2012. Cellular FLICE-like inhibitory proteins (c-FLIPs): fine-tuners of life and death decisions. Exp Cell Res. 318:1324-1331. IF: 3,580

Poltz R, M Naumann. 2012. Dynamics of p53 and NF-kappaB regulation in response to DNA damage and identification of target proteins suitable for therapeutic intervention. BMC Syst Biol 6:125. IF: 3,148

Sarto-Jackson I, I Milenkovic, KH Smalla, ED Gundelfinger, T Kaehne, R Herrera-Molina, S Thomas, MA Kiebler, W Sieghart. 2012. The cell adhesion molecule neuroplastin-65 is a novel interaction partner of γ-aminobutyric acid type A receptors. J Biol Chem. 287:14201-14214. IF: 4,773

Schaber J. 2012. Easy parameter identifiability analysis with COPASI. Biosystems. 110:183-185. IF: 1,784

Schaber J, R Baltanas, A Bush, E Klipp, A Colman-Lerner. 2012. Modelling reveals novel roles of two parallel signalling pathways and homeostatic feedbacks in yeast. Mol Syst Biol. 8:622. IF: 8,626

Schleich K, U Warnken, N Fricker, S Oztürk, P Richter, K Kammerer, M Schnölzer, PH Krammer, IN Lavrik. 2012. Stoichiometry of the CD95 Death-Inducing Signaling Complex: Experimental and Modeling Evidence for a Death Effector Domain Chain Model. Mol Cell. 47:306-319. IF: 14,178

Sewekow E, D Bimczok, T Kähne, H Faber-Zuschratter, LC Kessler, A Seidel-Morgenstern, HJ Rothkötter. 2012. The major soyabean allergen P34 resists proteolysis in vitro and is transported through intestinal epithelial cells by a caveolae-mediated mechanism. Br J Nutr 108:1603-1611. IF: 3,013


Publications 2011

Adrover MA, Z Zi, A Duch, J Schaber, A Gonzalez-Novo, J Jimenez, M Nadal-Robelles, J Clotet, E Klipp, F Rosas. 2011. Time-dependent quantitative multicomponent control of the G1-S network by the stress-activated protein kinase Hog1 upon osmostress. Science Sign 4, 192: ra63. IF: 6,354

Bechtloff R, A Goette, A Bukowska, C Wolke, T Kähne, B Peters, C Huth, U Lendeckel. 2009. Gender and age-dependent differences in the Bradykinin-metabolism within the pericardial fluid of patients with coronary artery disease. Int J Cardiol 146: 164-170. IF: 6,802

Bien J, O Sokolova, P Bozko. 2011. Characterization of Virulence Factors of Staphylococcus aureus: Novel Function of Known Virulence Factors That Are Implicated in Activation of Airway Epithelial Proinflammatory Response. J Pathog 2011: 601905. IF: -,-

Naumann M. 2011. Therapierelevante Forschung in der Inneren Medizin. Ärzteblatt Sachen-Anhalt 22: 25-26. IF: -,-

Neish AS, M Naumann. 2011. Microbial-induced immunomodulation by targeting the NF-kB system.  Trends Microbiol 19: 596-605. IF: 7,500

Maubach G, MC Lim, J Chen, H Yang, L Zhuo. 2011. miRNA studies in in vitro and in vivo activated hepatic stellate cells. World J Gastroenterol 17: 2748-2773. IF 2,240

Rieke C, A Papendieck, O Sokolova, M Naumann. 2011. Helicobacter pylori-induced tyrosine phosphorylation of IKKβ contributes to NF-κB activation. Biol Chem 392: 387-393. IF: 3,603

Sandoval R, A González, A Caviedes, F Pancetti, KH Smalla, T Kaehne, L Michea , E Gundelfinger, U Wyneken. 2011. Homeostatic NMDA receptor down-regulation via brain derived neurotrophic factor and nitric oxide-dependent signalling in cortical but not in hippocampal neurons. J Neurochem 118: 760-772. IF: 4,337

Schaber J, E Klipp. 2010. Model-based inference of biochemical parameters and dynamic properties of microbial signal transduction networks. Curr Opin Biotech 22: 109-116. IF: 8,486

Schaber J, M Flöttmann, J Li, CF Tiger, S Hohmann, E Klipp. 2011. Automated ensemble modeling with modelMaGe analyzing feedback mechanisms in the Sho1 branch of the HOG pathway. PLoS ONE 6: e14791. IF: 4,411

Tacke F, N Kanig, A En-Nia, T Kaehne, C Eberhardt, V Shpacovitch, C Trautwein, P Mertens. 2011. Y-box protein-1/p18 fragment identifies malignancies in patients with chronic liver disease. BMC Cancer 11: 185-204. IF: 3,153

Yu DM, L Slaitini, V Gysbers, AG Riekhoff, T Kähne, HM Knott, I De Meester, CA Abbott, GW McCaughan, MD Gorrell. 2011. Soluble CD26/dipeptidyl peptidase IV enhances human lymphocyte proliferation in vitro independent of dipeptidyl peptidase enzyme activity and adenosine deaminase binding. Scand J Immunol. 73: 102-111. IF: 1,935


Publications 2010

Backert S, M Naumann. 2010. What a disorder: proinflammatory signaling pathways induced by Helicobacter pylori. Trends Microbiol. 18: 479 - 486. IF: 6,894

Bukowska A, C Röcken, M Erxleben, FW Röhl, C Huth, MPA Ebert, U Lendeckel, A Goette. 2010. Atrial expression of endothelial nitric oxide synthase in patients with and without atrial fibrillation. Cardiovasc. Pathol. 19: e51 - e60. IF: 1,626

Cama G, T Jacobs, MI Dimaki, WE Svendsen, P Hauptmann, M Naumann. 2010. Disposable micro-fluidic biosensor array for online parallelized cell adhesion kinetics analysis on quartz crystal resonators. Meas. Sci. Technol. 21: 085801. IF: 1,317

Gnad T, M Feoktistova, M Leverkus, U Lendeckel, M Naumann. 2010. Helicobacter pylori-induced activation of β-catenin involves low density lipoprotein receptor-related protein 6 and Dishevelled. Mol. Cancer 9: 31. IF: 4,160

Mawrin C, C Wolke, D Haase, S Krüger, R Firsching, G Keilhoff, W Paulus, DH Gutmann, A Lal, U Lendeckel. 2010. Reduced activity of CD13/Aminopeptidase N (APN) in aggressive maningiomas is accociated with increased levels of SPARC. Brain Pathol. 20: 200-210. IF: 5,903

Mirastschijski U, R Schnabel, M Naumann, T Kähne. 2010. Novel plant metalloproteinase from Diffenbachia seguine caused fingertip necrosis. Br. J. Dermatol. 162: 1150-1152. IF: 4,260

Nishanth G, M Sakowicz-Burkiewicz, U Händel, S Kliche, X Wang, M Naumann, M Deckert, D Schlüter. 2010. Protective Toxoplasma gondii-specific T-cell responses require T-cell-specific expression of protein kinase C-theta. Infect Immun. 78: 3454-3464. IF: 4,205

Podhorecka M, A Skladanowski, P Bozko. 2010. H2AX Phosphorylation: its role in DNA damage response and cancer therapy. J. Nucleic Acids Aug 2010. pii: 920161. IF: -,-

Rieke C, T Kähne, K Schweitzer, B Schraven, J Wienands, M Engelke, M Naumann. 2010. Non-T cell activation linker regulates ERK activation in Helicobacter pylori-infected cells. Cell Signal. 22: 395-403. IF: 4,094

Rollié S, U Lendeckel, M Naumann, U Reichel, K Sundmacher. 2010. Dynamics of bionanoparticle targeting in mixtures of human tumour cells by validated population balance modelling. Soft Matter 6: 1203-1216. IF: 4,869

Schaber J, MA Adrover, E Eriksson, S Pelet, E Petelenz-Kurdziel, D Klein, F Posas, M Goksör, M Peter, S Hohmann, E Klip. 2010. Biophysical properties of Saccharomyces cerevisiae and their relationship with HOG pathway activation. Eur Biophys J. 39: 1547-1556. IF: 2,437

Schmeding M, S Rademacher, S Boas-Knoop, C Roecken, U Lendeckel, P Neuhaus, UP Neumann. 2010. rHuEPo reduces Ischemia-Reperfusion injury and improves survival after transplantation of fatty livers in rats. Transplantation 89: 161-168. IF: 3,498

Schweitzer K, M Naumann. 2010. Control of NF-κB activation by the COP9 signalosome. Biochem Soc Trans. 38: 156-161. IF: 3,378

Schweitzer K, O Sokolova, PM Bozko, M Naumann. 2010. Helicobacter pylori induces NF-κB independent of CagA. EMBO Rep. 11: 10-11. IF: 6,907

Valero T, G Moshopoulou, S Kintzios, P Hauptmann, M Naumann, Jacobs T. 2010. Studies on neuronal differentiation and signaling processes with a novel impedimetric biosensor. Biosens Bioelectron. 26: 1407-1413. IF: 5,429

Wartmann T, J Mayerle, T Kähne, M Sahin-Tóth, M Ruthenbürger, R Matthias, A Kruse, T Reinheckel, C Peters, FU Weiss, M Sendler, H Lippert, HU Schulz, A Aghdassi, A Dummer, S Teller, W Halangk, MM Lerch. 2010. Cathepsin L inactivates human trypsionogen. Whereas cathepsin L-deletion reduces the severity of pancreatitis in mice. Gastroenterol. 138: 726-737. IF: 12,899

Wex T, A Leodolter, J Bornschein, D Küster, T Kähne, S Kropf C Albrecht, M Naumann, A Rössner, P Malfertheiner. 2010. Interleukin 1 beta (IL1B) gene polymorphisms are not associated with gastric carcinogenesis in Germany. Anticancer Res. 30: 505-512. IF: 1,428

Last Modification: 06.07.2018 - Contact Person: Webmaster

Prof. Dr. Michael Naumann

Birgit Zittlau

Institute of
Experimental Internal Medicine

Medical Faculty
Otto von Guericke University
Leipziger Straße 44
D-39120 Magdeburg

phone: + 49 391 67 13227
fax: + 49 391 67 13312