Otto-von-Guericke-Universität Magdeburg

  Institute of Experimental Internal Medicine
 
 
 
 
 
 
 
 
 
 
 
 
research
 

Research

 

RESEARCH PROFILE OF THE INSTITUTE


Exploitation of regulatory signatures for therapeutic intervention in inflammation and cancer

The research program of the institute encompasses scientific projects on the regulation of cellular signal transmission in the molecular pathogenesis of inflammation and cancer. Cells respond to their environment and thereby activate distinct intracellular signal transduction pathways, involving the assembly of protein complexes within signaling cascades and a variety of protein modifications. Our studies mainly focus on clinically important signaling modules like one of the most important regulatory systems involved in the innate immune response and differentiation processes, the NF-κB network. For the comprehensive analysis of the regulatory networks in the cell, we rely on methods in mass spectrometry to evaluate the obtained data. In addition, the question of protein function is studied by innovative approaches of mathematical modeling of signal processes in cellular networks. The molecules of interest studied in the process of molecular pathogenesis could represent protein biomarkers. Herein, investigations of exclusive proteins with a special emphasis on predictive indicators of disease are beneficial for drug discovery and development.

  • NF-κB in health and disease
  • Helicobacter pylori infection biology
  • Mathematical modeling of cell processes
  • Mass spectrometry

 

Last Modification: 23.03.2016 - Contact Person: Webmaster
 
 
 
 

Director
Prof. Dr. Michael Naumann

Secretary
Birgit Zittlau

Institute of
Experimental Internal Medicine

Medical Faculty
Otto von Guericke University
Leipziger Straße 44
D-39120 Magdeburg

phone: + 49 391 67 13227
fax: + 49 391 67 13312
e-mail: ieim@med.ovgu.de


Ines Klaes
phone:  +49 391 67 17853
e-mail: drug-development@med.ovgu.de